Principal Scientist - Analytical Research and Development at Pfizer

OVERVIEW:

As a Principal Scientist, you will be at the center of our operations, and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute to the therapeutic area level and can represent the department on multidisciplinary teams.

With your deep knowledge of the discipline, you will work with internal and external partners around the world to manage and oversee GMP analytical readiness for novel small molecule components for use in targeted therapeutics. You will use strong communication skills to ensure technical and business line alignment across a variety of stakeholders within multidisciplinary teams. It is your scientific diligence, knowledge, and focus on execution that will help in making Pfizer ready to achieve new milestones and help patients across the globe. You will play a lead role in establishing an outsourcing culture and mindset within ARD.

ROLE SUMMARY:

As a member of the Pharmaceutical Sciences Analytical Research and Development team, you will collaborate with project teams, development analysts, GMP analysts and external vendors to deliver multiple units of analytical work in parallel. You will manage analytical testing through successful, timely delivery for internal project teams in support of small molecule drug development. You will apply your expertise in separations and chromatography as well as other analytical methodologies to enable drug development utilizing external resources.

The candidate will be responsible for independently delivering technical work packages in support of drug development during all clinical phases. Work will be predominantly focused on analytical development activities including validating and transferring analytical methods, developing, and executing general testing protocols aligned with ARD development workflows, critically evaluating vendor generated data and compiling summaries as required.

The role requires collaboration with ARD colleagues to identify appropriate analytical approaches, ensuring vendors clearly understand Pfizer's needs, managing technical risks, and developing appropriate contingencies across a dynamic portfolio. This role also requires direct interaction with outsourcing colleagues in partner groups and therefore requires knowledge of API and DP development workflows.

The candidate will manage differences in analytical instrumentation and operating procedures between the vendors and Pfizer, ensuring minimal technical impact on the work packages and data being delivered. The candidate will capture relevant feedback and facilitate the evolution of best practices and process improvements with the vendor.

BASIC QUALIFICATIONS:

• Ph.D. in Analytical Chemistry or related field with 4+ years of R&D experience OR Masters in Analytical Chemistry or relevant industry experience with 9+ years of R&D experience, OR B.S. with 12+ years of relevant industry experience and analytical development experience.

• Significant hands-on experience of the development and application of common analytical methods to support the progression of drug candidate development workflows.

• Good Knowledge of the development workflows used by ARD’s key partners within PSSM.

• Demonstrated ability to manage parallel projects, prioritize activities in a dynamic environment, meet timelines, and interact with multidisciplinary teams and stakeholders.

• A breadth of diverse leadership experiences and the ability to lead change and work in new paradigms.

• Attention to detail, strong organizational skills, and effective interpersonal and communication skills are required.

• Demonstrated oral and written communication skills, including visualization of data, presentations, and authoring technical articles

• Demonstrated ability to meet timelines and interact with multi-disciplinary teams.

• Demonstrated ability to learn new techniques and solve complex analytical problems.

• Demonstrated ability to work with contract manufacturing organizations.

• Attention to detail, strong organizational skills, and effective interpersonal and communication skills are required.

• Proficient with a wide variety of software and information systems.

• Good understanding of GMP as applied to analytical development.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENTAL REQUIREMENTS:

• Limited US and international travel may be required

ADDITIONAL DETAILS:

• Last date to apply is May 12, 2026

• Work Location Assignment: This is an on-site role at our Bothell campus requiring you to live within commuting distance and work on-site an average of 2.5 days per week.

The annual base salary for this position ranges from $106,000.00 to $176,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

Research and Development: