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Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description: Position Overview

We are seeking an energetic, highly motivated, and creative Principal Scientist to join us in our mission to implement new lipid nanoparticle (LNP)-based therapies for patients with autoimmune disorders in the Immunology Discovery organization. This role will be based in our Spring House, PA location. The ideal candidate has demonstrated expertise in LNP-based modifications of immune systems, particularly early-stage work (in vitro and in vivo systems). In this role, they will lead from the bench and develop and implement strategies for the in vitro and in vivo/ex vivo assessment of immune modulating LNP modalities.

You will be responsible for:

• Lead hands-on experimental work at the bench to develop and refine early-stage assays focused on immune modulation using lipid nanoparticle (LNP) technology. Drive scientific rigor in study design, execution, and troubleshooting to ensure robust and reproducible results.
• Develop and optimize experimental protocols, implement precise data collection strategies, and conduct thorough statistical analyses.
• Collaborate across multidisciplinary teams to accelerate assay development and facilitate preclinical research objectives. Communicate effectively with colleagues to share findings, address challenges, and advance project goals.
• Mentor and train junior scientists in experimental techniques, fostering their technical skills and professional development within a collaborative and communicative research environment.
• Document research in internal discovery reports, manuscripts for external publication, and other formats as required
• Present research at internal meetings and external scientific forums
• Work with leadership to establish and maintain involvement in any external collaborations required to support research goals

Qualifications:

• PhD in Immunology, Biological Sciences or Biomedical Engineering with at least 3-5 years of relevant industry experience (academic experience post-graduate also considered) OR a BS or MS in Biological Sciences, Biomedical/Immunology with 5-7 years of experience.
• Demonstrated knowledge and hands-on experience with approaches and technologies relevant to lipid nanoparticle (LNP) therapy is required.
• Experience with in vitro cell culture (primary cells from human, NHP and murine origin) and associated technologies of assessment of cellular and protein function (multi-color flowcytometry, MSD/Luminex, quantitative PCR etc.) is required
• Experience with assessment of LNP technology in murine models required, in vivo techniques (rodent handling, dosing of therapeutic molecules is advantageous)
• Strong oral, written and fit-for-purpose communication skills
• Excellent interpersonal & collaborative skills with an ability to operate as part of a team in highly interdependent environment. Adaptable and responsive, and committed to completing tasks in a timely fashion
• This role may require up to 10% travel as needed.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers . Internal employees contact AskGS to be directed to your accommodation resource.

Required Skills: Preferred Skills:

Big Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability