Purpose

Our In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated in vivo pharmacologist with experience in the development of biologic antigen-directed therapeutics (Antibodies, Antibody Drug Conjugates, etc.). This individual will support the in vivo strategy and coordination for various pipeline projects, and responsibilities will include tumor model selection, study design preparation, hands-on in vivo data collection, data analysis and presentation to project teams and stakeholders. The scientist will collaborate in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists to advance oncology agents through the preclinical R&D pipeline. The ideal candidate will be highly motivated, work independently, have excellent communication skills and previous industry experience in the oncology field.

Responsibilities

• Independently conceive and execute in vivo experiments utilizing human tumor models (CDX, PDX, orthotopic models) in immunocompromised mice.
• Strategize, design, execute and analyze in vivo data to assess the efficacy, PK and PD of novel therapeutics.
• Manage study operations within the team, including the coordination of study designs and timelines/resources.
• Critically evaluate scientific literature and external resources to identify innovative concepts, methods, or technologies and apply them effectively to solve problems and improve outcomes.
• Effectively collaborate across cross-functional teams, presenting research findings to project teams/governance bodies and preparing technical reports.
• Work with external contract research organizations to advance our understanding of oncology diseases.
• Understand and adhere to IACUC protocols regarding animal welfare and handling.
• Mentor and guide one or more scientists in the group, evaluating and ensuring their effective performance. People-management responsibilities will be dependent on previous experience.

Qualifications

• Bachelor’s Degree or equivalent with 12+ years of experience, Master’s Degree with 10+ years of relevant experience, or PhD with 4+ years of relevant experience. A degree in cancer biology, immunology, pharmacology, or a related discipline with extensive hands-on experience with in vivo tumor model execution. Drug development experience in a pharmaceutical or biotech industry setting is highly desired.
• Proficient hands-on experience with in vivo tumor model development, including tissue harvesting, tumor inoculation and dosing via different routes/sites (SC, IP, PO, IV).
• Extensive knowledge of oncology and tumor biology with a proven publication record.
• Excellent critical thinking skills to support efficient study planning and execution and troubleshooting.
• Proactive and able to manage multiple responsibilities, adapt to changing priorities and able to meet deadlines in a fast-paced environment.
• Excellent verbal and written communication skills and the willingness to work and build strong relationships with peers in a multidisciplinary team.
• Flexibility and motivation to learn techniques and accomplish goals outside those stated above.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of thisposting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location,and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission,incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless anduntil paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

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About Abb Vie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.