Sr Scientist I Pharmacology at AbbVie

Purpose:

Drive the discovery of innovative therapies and treatments for obesity by designing and executing creative experimental strategies grounded in molecular pharmacology, with emphasis on GPCR signaling, trafficking, and efficacy. Lead efforts to develop and optimize advanced in-vitro biochemical and cell-based assays to produce high-quality data with direct translational impact. Propel scientific innovation in GPCR pharmacology and obesity research by fostering robust, cross-functional collaborations, integrating multidisciplinary expertise, and leveraging technological advancements to accelerate drug discovery.

Responsibilities:

• Demonstrate scientific initiative and creativity in GPCR pharmacology research and development activities.

• Independently develop and validate cell-based and biochemical assays to characterize GPCRs.

• Apply advanced techniques to assess biased agonism, receptor internalization, trafficking, and signaling pathway modulation.

• Utilize high-throughput screening methods to identify novel GPCR modulators.

• Implement emerging technologies, such as biosensor assays and CRISPR-based gene editing, for assay development.

• Analyze and interpret complex data to draw conclusions and inform decision-making.

• Collaborate with cross-functional teams, including chemists, to support obesity research projects and SAR analyses.

• Maintain accurate and detailed records of experiments and results and adhere to corporate safety and compliance standards.

• Serve as primary author for scientific and regulatory reports and present findings to appropriate stakeholders.

• Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary.

• Degree in Pharmacology, Cell Biology, Biochemistry, or related discipline (preferred), with relevant post graduate experience.

• Familiarity with quantitative assay development, data analysis, and interpretation in drug discovery.

• Experience in obesity, metabolic, or related disease area research is strongly preferred.

• Demonstrated ability to think independently, troubleshoot, and lead projects.

• Experience with laboratory automation and high-throughput screening is a plus.

• Demonstrated ability to thrive in a fast-paced, cross-functional, and dynamic environment, function independently, communicate effectively, and collaborate closely with others.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time ofthis posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location,and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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About Abb Vie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.