Senior Scientist I - Cell Line Development

We are seeking a highly motivated senior scientist to join our multidisciplinary team focused on developing robust production cell lines to enable Abb Vie’s clinical and commercial biologics pipeline. In this lab-based position, the senior scientist will contribute to the development, characterization, and optimization of mammalian host and production cell lines, with a strong emphasis on CHO-based cell line development to support enhanced recombinant protein productivity, improved product quality, and streamlined process efficiency. The successful candidate will play a key role in advancing the Biologics pipeline through cell line development, clone characterization, and collaboration with cross-functional teams. Experience with modern technologies such as CRISPR-Cas9, Cas-Clover, NGS, omics, bioinformatics, systems biology, artificial intelligence (AI), machine learning (ML), high-throughput automation, and digitalization for cell line and process optimization is highly desirable.

Responsibilities:

• ​​Develop, characterize, and optimize CHO host and production cell lines to support pipeline progression and improve process performance.

• ​Apply cell line development strategies to identify, evaluate, and advance robust clones with desirable productivity and product quality attributes.

• ​Support implementation of advanced technologies to accelerate cell line development workflows and improve decision-making.

• ​Conduct laboratory research independently, including troubleshooting of experiments, methods, and equipment as needed.

• ​Apply creative and analytical thinking to solve complex scientific problems and communicate ideas effectively to diverse audiences.

• ​Author and review technical reports; present data to the team and leadership; review literature; and contribute scientific insights to project teams.

• ​Serve as the CLD representative on cross-functional teams and collaborate closely with cell line development, cell culture, analytical, purification, bioinformatics, and other functional colleagues to support project timelines and deliverables.

• ​Manage multiple projects across therapeutic programs in a dynamic and fast-paced team environment. ​

• Contribute to continuous improvement of cell line development platforms, workflows, and technologies.

• Bachelor’s degree in a scientific field with at least 10 years of related work experience; Master’s degree in a scientific field with at least 8 years of related work experience; or PhD in a scientific field with 0–2 years of related work experience.

• ​Strong background in cell biology, molecular biology, and cell line development, with extensive experience in mammalian cell culture and aseptic technique.

• ​Experience with CHO cell culture, clone screening, stability assessment, productivity characterization, and/or cell line optimization is highly desirable.

• ​Working knowledge of regulatory filing expectations, documentation standards, and support for submission-ready cell line development packages is preferred.

• ​Experience with omics, genetic engineering, flow cytometry, fluorescence-activated cell sorting (FACS), next-generation sequencing, bioinformatics, systems biology, machine learning (ML), artificial intelligence (AI), and/or modeling methods is a plus, but not the primary focus.

• ​Demonstrated ability to independently design and execute experiments, interpret data, and identify appropriate follow-up strategies.

• ​Proven track record of teamwork, adaptability, innovation, initiative, and integrity; global mindset to thrive in a diverse culture and environment.

• ​Ability to work effectively with diverse internal and external collaborators.

• ​Ability to multitask and deliver within timelines in a dynamic, fast-paced setting.

​Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​
• This job is eligible to participate in our short-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

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