Process Safety and Development Engineer

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Laboratory Setting

About the Role

As part of the Thermo Fisher Scientific team, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every single day to enable our customers to make the world healthier, cleaner and safer. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step beyond by developing solutions for some of the world's toughest challenges, like protecting the environment, making sure our food is safe or helping find cures for cancer.

You'll be based in our Florence, South Carolina location, where you'll have the opportunity to work in a dynamic environment that fosters innovation and collaboration. You will support our Drug Substance Division at Thermo Fisher Scientific and play an important role in our company's success.

An excellent early-career opportunity in Manufacturing Services for learning engineering process development in the API Pharmaceutical CDMO industry. This role supports process safety at both Florence East & West sites, and will employ a variety of calorimetry instruments, automated reactors, and process analytical technology (PAT), interfacing closely with EHS, PRD, Engineering, and Operations. Additional projects, involving reaction kinetics, distillation, stripping, extraction, crystallization, isolation, and drying operations, will range from troubleshooting, to optimization, to hazard risk mitigation, and will focus on bringing engineering perspective and expertise to ensure successful scale-up and robust operability in the plants.

A Day in the Life

• Conduct thermal hazard screening on starting materials, intermediates, products, and high-energy reagents using differential scanning calorimetry (DSC)
• Conduct follow-on experimentation using accelerating rate calorimetry (ARC) and ARSST
• Conduct reaction calorimetry studies (Easy Max & RC1) to characterize the enthalpies for the desired chemistry
• Identify potential scale-up issues tied to heat or mass-transfer limitations in the plant equipment
• Conduct crystallization, isolation, extraction, distillation, and drying studies, as needed
• Assist and/or lead in the generation of risk analysis (RA) and PHA documents
• Issue and approve PHA documents in our electronic document management system (EDMS)
• Collect reliable process data through designed laboratory experiments with accurate, detailed documentation for process evaluation, development and troubleshooting
• Record and analyze scientific data/observations in detail
• Summarize and interpret process data to draw logical conclusions
• Write technical updates/reports
• Participate in technical discussions with internal teams and clients
• Use analytical instrumentation for mixture characterization including IR, HPLC, GC, and MS, as needed
• Provide timely technical support for scale-up production, quality and other inter-departmental needs

Qualifications

Education

• BS in Chemical Engineering, or related field required
• Advanced coursework/background in Physical and Organic Chemistry preferred

Experience

• At least 6 Months to 3 years of related experience in a regulated environment is required
• Co-Op experience will also be accepted
• Experience mentoring colleagues and providing technical training highly preferred

Knowledge, Skills, Abilities

• Proven ability to lead complex investigations and implement effective solutions
• Excellent verbal and written communication skills
• Ability to work collaboratively in a matrix environment
• Proficiency with statistical analysis software and Microsoft Office suite

Benefits

We offer competitive remuneration, annual incentive plan bonus scheme, healthcare, and a range of employee benefits! Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation.

About Thermo Fisher Scientific

As the world leader in serving science, our colleagues develop critical solutions through innovation—and build rewarding careers. Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.

Equal Opportunity

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Thermo Fisher Scientific is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, creed, religion, color, national or ethnic origin, citizenship, sex, sexual orientation, gender identity and expression, genetic information, veteran status, age or disability status.