Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Fall 2026 Co-op Program: July – December 2026

Co-op: Screening & On-target NGSDepartment: Screening & NGS

Assignment Overview

Prime Medicine is seeking a highly motivated co-op to join the Screening & NGS team supporting Prime Editing programs. This role will contribute to high-throughput genome editing experiments in mammalian systems and sequencing-based evaluation of editing outcomes.

The candidate will work at the interface of cell biology, genome editing, next-generation sequencing (NGS), and lab automation. In addition to supporting active screening efforts, the co-op will lead a defined project to optimize and automate components of the screening workflow to improve throughput, reproducibility, and data quality.

This position offers hands-on experience with cutting-edge gene editing technologies in a fast-paced, collaborative R&D environment focused on developing transformative genetic medicines. We seek a driven team member passionate about advancing human health.

Primary Responsibilities:

• Maintain and manipulate mammalian cell cultures using aseptic technique

• Perform cell transfections and execute gene editing experiments

• Isolate genomic DNA, prepare NGS libraries, and operate Illumina sequencing platforms

• Support development of automated liquid handling workflows

• Analyze and interpret sequencing data to assess editing efficiency and screening performance

• Maintain accurate experimental documentation using an electronic lab notebook system

Qualifications:

• Pursuing a B.S. or M.S. in Molecular Biology, Genetics, Bioengineering, or related field

• Hands-on experience with core molecular biology techniques, including PCR and DNA extraction

• Experience with aseptic technique

• Familiarity with genome editing concepts

• Exposure to NGS workflows or sequencing-based assays

• Strong attention to detail, troubleshooting ability, and collaborative mindset

Preferred Qualifications:

• Prior mammalian cell culture experience strongly preferred

• Hands-on experience with gene editing and/or NGS techniques

• Experience with laboratory automation and/or data analysis

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education.

U.S. Pay Range
$23—$33 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.