Postdoctoral Fellow-MSH-32076-169

Salary: According to UAW/Mount Sinai agreement, effective 7/1/25 starting salary $74,692

Department: 866 – Department of Immunology and Immunotherapy

Location: Hess – 1470 Madison Ave., 5th Fl., New York, NY 10029

Department website: https://icahn.mssm.edu/about/departments-offices/immunology-immunotherapy

Laboratory website: https://www.thebrodylab.org/

Qualifications:

• Ph.D. required

• Experience working in a research laboratory setting

• This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee

• UAW.

Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW-_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf.

• SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 866 - Immunology and Immunotherapy
• ISM, Icahn School of Medicine

The Brody Laboratory is seeking highly motivated postdocs to lead projects aimed at Improving the Anti-Tumor Immune Response Induced by in situ vaccination.

Goals/Outcomes of the Research Project: the current phase of this longstanding Project is to potentiate tumoral recruitment of professional Antigen Presenting Cells, particularly type 1 Dendritic Cells (DC1) and assess the impacts on presentation and cross-presentation of surrogate and neo-epitope tumor antigens to tumor-reactive T cells as well as their subsequent priming and induction of systemic anti-tumor immune response. Recent advances in the development and understanding of mRNA-lipid nanoparticles has facilitated our preliminary data showing that specific DC-recruiting chemokines can be mRNA-encoded and produced by tumors in vitro and in vivo to increase DC1-migration.

Technical Duties:

• Perform independent research in the area of cancer immunotherapy and molecular biology, to develop in silico, in vitro, and in vivo data and models to assess the impact of chemokine-mRNA-LNP therapy on DC1 recruitment and induction of in situ vaccinal anti-tumor effects.
• Critically analyze data quality and results, communicate results to scientists and lay people
• Write or assist in writing scientific papers and grants
• Collaborate closely with other scientists to conduct research