At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company, based in Boston, Massachusetts, is a clinical-stage company. The company focuses on developing one-time gene editing medicines for cardiovascular disease. Founded by leaders in cardiovascular medicine, human genetics, and gene editing, Verve aims to replace treatment paradigm from chronic diseases management to novel ‘once and done’ single-course gene editing therapeutics. The company’s advanced development programs – VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease.

Lilly is seeking a Scientific Advisor with a proven track-record in scientific research and cross-functional teamwork to join the Analytical Research and Development (ARD) team within Lilly Research Labs focused on Verve Therapeutics products. This individual will develop and implement new analytical methods and technologies to characterize mRNA, gRNA, and LNP drug products for our growing gene editing pipeline. The position will be part of an integrated R&D team that aims to advance preclinical gene editing candidates into the clinic. The Advisor will work closely with discovery research, process development, and analytical development groups to ensure analytical excellence throughout the product development lifecycle.

Responsibilities:

This role is responsible for leading the analytical characterization of gene editing therapeutics, including method development, cross-functional collaboration, and regulatory support. The Advisor will design, develop, and qualify phase-appropriate analytical methods to support preclinical and clinical programs.

• Provide technical expertise for the analytical characterization of gRNAs, mRNAs, and lipid nanoparticle (LNP) drug products.
• Lead cross-functional interactions and serve as the analytical lead to plan and execute complex characterization studies.
• Develop and implement analytical methods for release and stability testing, product characterization, and high-throughput analysis.
• Collaborate with key partners across discovery research, preclinical, and process development to develop analytical platforms and provide analytical support.
• Author and review technical reports and regulatory submissions.
• Present data to internal teams and across the organization.

Basic Requirements:

• Ph.D. in biophysics, biochemistry, bioengineering, biology or related life sciences field

Additional Skills/Preferences:

• Significant research experience with molecular biology, biochemistry, genome editing, and CRISPR-Cas9 technology
• Hands-on experience with mammalian cell culture, cloning, and PCR techniques including RT-qPCR.
• Previous experience with oligonucleotide lipid nanoparticles, short and large oligonucleotide analytics, protein engineering, and process development.
• Demonstrated competency in operating lab automation instrumentation such as Hamilton and TECAN.
• Proficient in advanced spectroscopy and/or microscopy for oligonucleotide and protein analytics.
• Strong change and learning agility with a proven history of bringing new ideas and creativity, both scientifically and strategically.
• Proven ability to thrive in a fast-paced, dynamic environment with demonstrated adaptability.
• Prior experience contributing to and leading cross-functional teams to achieve organizational goals.
• Strong interpersonal skills with the ability to work by influencing peers and managing multiple priorities in project delivery.

Additional Information:

• This is an on-site, lab-based role.

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Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$138,000 - $224,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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